FDA-Approved Treatment
Spravato for Depression
Spravato (esketamine) is an FDA-approved nasal spray that offers new hope for patients with treatment-resistant depression. Administered in our office with close clinical monitoring, it works rapidly — often when other treatments have not.
How It Works
A breakthrough for treatment-resistant depression
Spravato contains esketamine, a form of ketamine that targets the brain's NMDA receptors and glutamate system. This mechanism is fundamentally different from traditional antidepressants, which is why it can work when SSRIs, SNRIs, and other medications have not.
As the first FDA-approved treatment in a new class of antidepressants, Spravato represents a significant advance in psychiatric care — offering rapid relief and a new path forward for patients who have struggled to find effective treatment.
FDA-approved for treatment-resistant depression and MDD with suicidal ideation
Rapid onset — many patients experience improvement within days
Administered in-office under clinical supervision with a 2-hour monitoring period
May be covered by insurance — unlike IV ketamine infusions
Who It Helps
Is Spravato right for you?
Spravato is FDA-approved for adults with specific diagnoses who have not responded adequately to prior antidepressant treatment. A comprehensive evaluation helps us determine if you meet the criteria.
REMS Program & Safety
Spravato is only available through a restricted distribution program called the Spravato REMS (Risk Evaluation and Mitigation Strategy). This means it can only be administered in certified healthcare settings — like ours — where patients are monitored for at least 2 hours after each dose.
Northern Lights Psychiatry is a certified Spravato treatment center. Our team is trained in the REMS program requirements to ensure your safety throughout every session.
What to Expect
Your Spravato journey
Psychiatric Evaluation
We conduct a thorough evaluation to confirm a diagnosis of treatment-resistant depression or MDD with suicidal ideation and review your prior treatment history.
Insurance & Prior Authorization
Our team works with your insurance to obtain prior authorization for Spravato, which is covered by many plans when criteria are met.
In-Office Treatment Sessions
You self-administer the nasal spray under our supervision. You remain in our office for 2 hours after each dose for monitoring. You will need a driver home.
Ongoing Monitoring & Support
Spravato is used alongside an oral antidepressant. We monitor your response closely and adjust your overall care plan to support lasting improvement.
Common Questions
Frequently asked questions
Take the Next Step
Find out if Spravato is right for you
Schedule a consultation with our team to discuss your history, prior treatments, and whether Spravato may be a good fit for your care plan.